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Danai Topouza

MSc Student | Queen's University | Kingston, Canada

I work in The Computational Genomics Laboratory, where I analyze RNA-sequencing data to understand the underlying mechanisms of chemotherapy resistance in ovarian cancer.

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My current thesis work investigates the biological networks and genomic variants that modulate chemotherapy response in ovarian cancer patients; through analysis of RNA-sequencing patient data, I aim to discover gene variants and networks that are involved with chemotherapy resistance.

My study of the genes and networks associated with platinum therapy response reveals novel biological pathways, which may underlie the mechanisms of chemoresistance. I hope that this will ultimately facilitate genetic testing, promote novel drug development, and improve the efficacy of chemotherapy.

Education and Experience

I have completed my undergraduate training at Queen's University, graduating with a BScH in Biology and a minor in Computer Science. I have since begun my MSc in the Experimental Medicine program at the Queen's Department of Biomedical and Molecular Sciences, under the supervision of Dr. Qingling Duan.

With a background in molecular genetics and computing, I hope to combine my expertise to investigate the underlying mechanisms of disease traits. My previous work includes investigating the mechanisms of programmed cell death in Saccharomyces cerevisiae through transcriptomic analysis of RNA-sequencing data.

Danai Topouza CV